The efficacy of a nitroimidazole containing regimen for the treatment of Helicobacter pylori infection is decreased by nitroimidazole resistance. Nitroimidazoles are metabolized by Helicobacter pylori by several nitroreductases of which an oxygen- insensitive NADPH nitroreductase encoded by the rdxA
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A study of rdxA gene deletion in metronidazole resistant and sensitive Helicobacter pylori isolates in Kerman, Iran
Introduction and objective: Metronidazole (Mtz) resistance in Helicobacter pylori has been found to be associated with mutations in rdxA, a gene encoding an oxygen insensitive NADPH nitroreductase, and enhanced by mutations in frxA a gene encoding a NAD(P)Hflavin oxidoreductase. In this study, we examined the prevalence of rdxA deletion among local isolates of H. pylori. Materials and methods: ...
متن کاملRoles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole.
The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in metronidazole (MTZ) susceptibility and resistance has been controversial. Jeong et al. (J. Bacteriol. 182:5082--5090, 2000) had interpreted that Mtz(s) H. pylori were of two types: type I, requiring only inactivation of rdxA to became resistant, and type II, requiring inactivation of both rdxA and frxA t...
متن کاملThe role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pylori.
It was recently demonstrated that inactivation of the rdxA gene, which encodes an oxygen-insensitive NADPH nitroreductase, is associated with the development of resistance to metronidazole by Helicobacter pylori. In order to further evaluate the contribution of rdxA to metronidazole resistance, the sequence of the rdxA gene was determined for a series of metronidazole-sensitive and -resistant i...
متن کاملShort-term infection with Helicobacter pylori and 1 week exposure to metronidazole does not enhance gastric mutation frequency in transgenic mice.
The aim of this study was to determine whether exposure of Helicobacter pylori-infected mice to metronidazole resulted in the delivery of mutagenic compounds to the gastric epithelium via the oxygen-insensitive NADPH nitroreductase (RdxA) of H. pylori. C57BL/6 transgenic mice containing the lambda/lacI transgene were inoculated with peptone trypsin broth, H. pylori SS1 or SS1-rdxA(-), an SS1-de...
متن کاملSources of variation of Helicobacter pylori treatment success in adults worldwide: a meta-analysis.
BACKGROUND A vast number of Helicobacter pylori treatment trials have been conducted. Regimens may vary in efficacy in different patient populations. METHODS We identified sources of treatment effect variation from 618 treatment groups using weighted cross-classified multi-level meta-regression models. Summary effect estimates were calculated within groups that lacked identified heterogeneity...
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تاریخ انتشار 2000